Cysteines Involved in the Interconversion Between Dehydrogenase and Oxidase Forms of Bovine Xanthine Oxidoreductase
نویسندگان
چکیده
منابع مشابه
Crystal structures of bovine milk xanthine dehydrogenase and xanthine oxidase: structure-based mechanism of conversion.
Mammalian xanthine oxidoreductases, which catalyze the last two steps in the formation of urate, are synthesized as the dehydrogenase form xanthine dehydrogenase (XDH) but can be readily converted to the oxidase form xanthine oxidase (XO) by oxidation of sulfhydryl residues or by proteolysis. Here, we present the crystal structure of the dimeric (M(r), 290,000) bovine milk XDH at 2.1-A resoluti...
متن کاملUnique amino acids cluster for switching from the dehydrogenase to oxidase form of xanthine oxidoreductase.
In mammals, xanthine oxidoreductase is synthesized as a dehydrogenase (XDH) but can be readily converted to its oxidase form (XO) either by proteolysis or modification of cysteine residues. The crystal structures of bovine milk XDH and XO demonstrated that atoms in the highly charged active-site loop (Gln-423-Lys-433) around the FAD cofactor underwent large dislocations during the conversion, b...
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15 صفحه اولP-91: Vitamin E and Selenium Supplementation Affects Aldehyde Oxidase, Xanthine Dehydrogenase/Oxidase Activities In Diabetic Rat Ovaries
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ژورنال
عنوان ژورنال: Journal of Dairy Science
سال: 2000
ISSN: 0022-0302
DOI: 10.3168/jds.s0022-0302(00)74909-5